Resident Evil 4 Remake: Regenerators [Complete Guide]

Here is how you can defeat the infamous Regenerators in Resident Evil 4 Remake.

regenerators re4 remake resident evil
Regenerators in Resident Evil 4 Remake
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Resident Evil 4 Remake is known to have some of the most creative enemy designs. This keeps the gameplay fresh and keeps you on the edge of your seat. In the initial chapters, you start with the mindless infected villagers, and later on, you meet the tentacle Plaga A monsters. However, this guide will help you understand and defeat the infamous Regenerators from Resident Evil 4 Remake.

Key Takeaways

  • Regenerators are an enemy type you can encounter in Chapter 13 and Chapter 14 of the game.
  • These enemies can lurk in the facility’s hallways where Ashley Graham is kept.
  • The Regenerators can regrow limbs and body parts where they are shot at. Moreover, they can extend their hands to grab Leon across a room.
  • Although, these Regenerators do have a weakness: parasites or Plagas hiding in their body. You must acquire the Biosensor Scope and attach it to your rifle to see these Plagas through the scope.
  • All you need to do is to shoot these Plagas to kill these Regenerators.
  • The Iron Maiden is the mutated second form of these Regenerators. These are stronger and harder to kill with needles sticking out of their body. The Iron Maiden can shoot out these needles as projectiles, which can cause severe damage.
  • Iron Maiden’s weak point, or Plaga, is within their heads, and you would need to shoot multiple times to kill it.
  • You can also go against a stronger Iron Maiden as part of the Merchant request, The Wandering Dead. This enemy contains more plaga and can take more bullets while shooting needles in your direction.

Regenerators In Resident Evil 4 Remake

Resident Evil 4 Remake hides its best enemies right around the corner. Therefore, whenever you think you are comfortable with one enemy type, they throw another one at you. The Regenerators might be one of the scariest monster types from the original game, and during this remake, they definitely received a significant makeover.

The Regenerators might be one of the scariest enemies you encounter in Resident Evil 4 Remake. These enemies are even larger than most enemies you will encounter. Moreover, the grey skin tone and the towering presence make these enemies even scarier. However, these enemies will throw the fans of the original game for a loop, as these enemies are not precisely like players would remember.

Moreover, these enemies are even more terrifying because this is not their only form. These already powerful enemies have another mutated type that’s even stronger than the first. The second mutation of the Regenerators is known as the Iron Maiden and will definitely scare even the most faithful of Resident Evil fans.

There are currently three types of Regenerators in the game. All three of these Regenerators have the same basic abilities and may look somewhat similar in appearance. However, players will soon realize these different forms possess a few new tricks, and their appearances become more grotesque with each mutation.

Regenerators – The Original Form

regenerators re4 remake resident evil 4
Regenerators – Image Captured by: Gamesual

These horrifying monsters look way scarier with the new graphics haul. With sharp fangs, glowing red eyes, and textured skin in the remake, these enemies send chills down every player’s spine. However, it’s not even the appearance that makes these enemies terrifying. The Regenerators received a major speed and attack boost in the Resident Evil 4 Remake.

The enemy type famous for being slow in the original is now fast and persistent in the Remake. So they will run around the facility trying to get a hold of you, and shooting will slow them down. Plus, they will not stop until you have moved on to a different section or completely killed them off.

Moreover, as the name suggests, these enemies can grow back their limbs and continue chasing you. So no amount of bullets will be able to keep them off your backs for long. They even have limbs that can stretch and attack you from a distance. However, even fully cut-off limbs will grow back after a while, so the Regenerators will fully heal once you return.

Additionally, if you shoot off their legs, the Regenerators will use their hands and upper body to jump toward you. This makes them even scarier, as you need to keep track of jumping monsters from the floor.

Knowing where these enemies will pop up is best so you are not surprised. The Regenerators make their first appearance in the final section of Chapter 13 of RE4 Remake. During this chapter, you are tasked with saving Ashley Graham from the Facility. However, this being a Resident Evil game, getting Ashley back will not be easy. You are taken around the facility’s insides, trying to navigate the rooms and locate Ashley.

However, once you locate her, the real problems begin. Your current objective becomes acquiring a key card and upgrading it level by level. This is also where you will first see the Regenerators lurking in the dark hallways. Therefore, now you need to run around upgrading your key card and trying to survive being attacked by these ungodly monsters. 

The Regenerators are not easy to kill at first. So it is best recommended to run in the opposite direction when you first encounter these creatures, as you will waste your precious ammo. However, in the later section, you are tasked with upgrading a key card in a frozen room. Upgrading the key card will take some time, and the Regenerator will be right before you.

You can use some ammo or parry with your knife to avoid their long incoming arms. Once you have your card upgraded, it is best to run to the next objective, where you will be taken to the lab. However, during this section is when the playing field gets leveled. This is the section where you will find the Biosensor Scope, which is vital in eliminating these enemies.

biosensor scope re4 remake resident evil
Biosensor Scope – Image Captured by: Gamesual
biosensor scope location re4 remake resident evil
Location of Biosensor Scope – Image Captured by: Gamesual

Your current objective is to upgrade the card to the final third level inside the Incubation Lab. Although, you need a wrench to open the slot where you will insert the key card. This is also the section where you will find the Thermal Scope or the Biosensor Scope. Here you are finally told that these monsters have a weakness. Firstly you would need to attach your scope to an Assault Rifle.

Now, you need to view these Regenerators through the scope, and you will see parasites or organisms (Plagas) within their body. Therefore, you would need to shoot these organisms to kill these Regenerators for good. These organisms would be glowing orange through the scope. Once you have shot all these organisms, the Regenerators will explode and fall to the ground. 

weakness regenerators plaga
Plagas Inside Regenerators – Image Captured by: Gamesual

Moreover, you will see the wrench inside one of these Regenerators. Just shoot the vat and shatter the glass, throwing the Regenerator out and ready for a fight. Again it is recommended to avoid fighting these creatures as much as possible, which is why you should avoid breaking any more vats.

Iron Maiden – The Second Form Of Regenerators

iron maiden in Resident Evil 4
Iron Maiden – Image Captured by: Gamesual

The Iron Maiden is the even more terrifying form of the Regenerators in the RE4 Remake. These monsters also made their appearance in the original Resident Evil 4. However, the Iron Maiden was a different strain of the Regenerators you encountered in the original. Although, in the Remake, these creatures are a second form of the Regenerators. 

These monsters are formed once you have received enough bullets inside a Regenerator and have killed all the parasites.  The Regenerator might look like they are about to die; instead, they come back alive as the Iron Maiden. These look like Regenerators with one very distinct add-on; now, they have hundreds of spikes sticking out of their bodies.

This is a horrifying sight, as the already unkillable monster is coming after you and shooting needles out of this body. On top of the original attack, where these creatures used their limbs to pull you toward them, they can now shoot needles out of their body. So now, even at a distance, Leon is not safe.

You will encounter the Iron Maidens in Chapter 14 of the game, so ensure you are prepared. Moreover, it is important to remember that not all the Regenerators will transform into the Iron Maidens. However, you will only discover once you have shot all the parasites or the Plagas within the body. The Regenerator will either die after this or mutate into the Iron Maiden variant.

Furthermore, you will see it happening as the Regenerator returns alive instead of dying. The revived form is the Iron Maiden and will shoot needles, so it is best to use corners to your advantage and avoid getting stabbed. These creatures will also be roaming the hallways of the facility.

The Iron Maidens are the mutated form of the Regenerators, so killing them is very much the same. However, once you have killed the Plagas in the body and the creature transforms into the Iron Maiden, you will see the parasite within the head. Iron Maiden’s weak point is within their heads, but killing these monsters is no easy task. 

iron maiden plagas re4 remake
Plagas Inside Iron Maiden – Image Captured by: Gamesual

You were able to take out parasites within the Regenerator’s body with a single rifle shot; this is not the case with Iron Maidens. These monsters are built like tanks; you must repeatedly shoot their weak points to take them down. Moreover, once you have gotten a shot in their heads, these creatures will be momentarily stunned, and this is your opportunity to shoot more.

Furthermore, it is best to take out their legs at the start so they are slower and easier to shoot. However, it would be best to remember that they can still shoot spikes even on the floor. The Iron Maidens, even when dying, can give out significant damage. You will see these creatures shaking before they die, and upon their death, they will explode, shooting needles in all directions.

Regeneradors – The Strong Threat

The Regenerador can be considered another mutated form of the Iron Maiden. As part of the Merchant request, The Wandering Dead, you will have to fight this sort of a boss of all the Regenerators. Moreover, you will get this Merchant request during Chapter 14, once Ashley has taken down the Cargo Depot walls with a wrecking ball.

The request wants you to kill an even more potent version of the Iron Maiden that has spawned within the Incubation lab. It is best to hide Ashley before you pick on the monstrous creature. This version of the Iron Maiden will have many Plagas within its body, and killing a single Plaga will not stun the enemy. The Strong Threat will chase you until you finally put it down.

Moreover, the attacks will stay the same as this is another form of the Iron Maiden. You will have to avoid the flying needles and the elongating limbs. The creature is also built like a tank, so make sure your ammo situation is good before you take on the enemy. Just equip the Biosensor Scope on your Rifle, potentially the Stingray. Keep shooting the weak point until the enemy finally goes down.


The enemy types are incredibly diverse in Resident Evil 4 Remake. As the game progresses, these enemies become more intelligent and attack faster. The earlier enemies were easier to kill and fight. However, the enemies you encounter later on become harder to kill. As a result, players are always on the edge of their seats, and RE4 never gets repetitive.

The Regenerators are introduced to us during the final phase of Chapter 13 of Resident Evil 4 Remake. Players of the original can recognize these formidable foes instantly. Although, in the Remake, these Regenerators are faster and deadlier. These enemy types can regenerate, so shooting them does not kill them. Later, players are introduced to the Biosensor Scope and told about the Regenerator’s weakness.

Their second form, the Iron Maidens, can terrify even the veteran players. These needle-throwing counterparts are even harder to kill and have a scarier character design. This adds to your adrenaline rush and is even more satisfying once you kill them. Hopefully, you are prepared once you take on these foes because if you panic, it is quite possible that Leon will not make it out alive.

Check out more of our guides on solving the Resident Evil 4 remake puzzles:

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